IMPACT OF A PHYSICIAN-LED EXERCISE PROGRAMME ON QUALITY OF LIFE, MUSCLE MASS AND CLINICAL RESPONSE IN INFLAMMATORY BOWEL DISEASE PATIENTS DURING INDUCTION WITH DISEASE-MODIFYING THERAPY: A STUDY PROTOCOL

Impact of a physician-led exercise programme on quality of life, muscle mass and clinical response in inflammatory bowel disease patients during induction with disease-modifying therapy: a study protocol

Introduction Biologic and small-molecule therapies have revolutionised the treatment of moderate-to-severe inflammatory bowel disease (IBD).A significant proportion of patients experience early or delayed treatment failure.Patients with IBD with greater visceral obesity are less likely to respond to biologics.Sarcopenia has been identified as a pre

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Hypothalamic vasopressinergic projections innervate central amygdala GABAergic neurons: implications for anxiety and stress coping

The arginine-vasopressin (AVP)-containing hypothalamic magnocellular neurosecretory neurons (VPMNNs) are known for their role in hydro-electrolytic balance control via their projections to neurohypophysis.Recently, projections from these same neurons to hippocampus, habenula, and other brain regions, in which vasopressin infusion modulates continge

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DWSTr: a hybrid framework for ship-radiated noise recognition

The critical nature of passive ship-radiated noise recognition for military and economic security is well-established, yet its advancement faces significant obstacles due to the complex marine environment.The challenges include natural sound interference and signal distortion, complicating the extraction of key acoustic features and ship type ident

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Future perspectives for PDE5 inhibitors bridging the gap between cardiovascular health and psychological status

Abstract The serendipitous discovery that inhibiting type 5 phosphodiesterase (PDE5) using sildenafil, a potent PDE5 inhibitor (PDE5i) initially developed for cardioprotection, introduced the possibility of orally managing erectile dysfunction (ED) led to an increase in research data, which are currently considered groundbreaking for the new discip

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Pleural abrasion versus apical pleurectomy for primary spontaneous pneumothorax: a systematic review and Meta-analysis

Abstract Background Surgical approach is the most lovesense 3 effective treatment for primary spontaneous pneumothorax.The two most widely adopted surgical methods are mechanical abrasion and apical pleurectomy, in addition to bullectomy.We performed a systematic review and meta-analysis to examine which technique is superior in treating primary sp

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